Sampling strategies, such as the measurement of drug concentration 2 h after oral administration, have been used in a variety of settings to estimate systemic exposure to Neoral measured as the area under the blood concentration curve AUC of the drug in blood. Smith and H. A Systolic blood pressure Neoral population. Summary of the main differences in efficacy results between the Neoral and SIM groups. Volume This can be harmful or prevent the drug from working well. The improved bioavailability of the microemulsion formulation is reflected in a reduced requirement for dose increases over time. It is not known whether this medicine will harm an unborn baby. Do you have high blood pressure? It is thought that rheumatoid arthritis may be caused by inappropriate immune responses in your body. Only remove them when it is time to take your medicine. An international consensus report: the use of cyclosporin A in rheumatoid arthritis. If you take too much: You could have dangerous levels of the drug in your body. Indications for NEORAL: Organ rejection prophylaxis in allogeneic kidney, liver, and heart transplant patients, in combination with azathioprine and corticosteroids. Leave your capsules in the foil. View Metrics. Furthermore, the variation in bioavailability may be decreased with Neoral, which is of importance given the safety issues associated with CyA treatment. The investigators study is the first clinical trial to compare the effect of Iminoral versus Neoral in preventing acute rejection in renal transplantation and also to compare the side effects of these two drugs. Daily news summary. Read more on Autoimmune Resource and Research Centre website. Do not stop taking your medicine unless your Nepral tells you to, however well you feel. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. This Information Sheet is about some of the common medications drugs used to treat autoimmune illness. Discontinue if adverse events are severe or persistent. Drug: Iminoral Drug: Neoral. Search for terms x. More rarely, headaches, skin rash, increased weight, fluid retention, confusion, feelings of numbness or tingling, muscle weakness or cramps, fits, gout, raised cholesterol levels, slight swelling of the breast tissue, changes in the menstrual period in women and tumours have also been reported. To help avoid interactions, your doctor should manage all of your medications carefully. Healthdirect Australia is not responsible for the content and advertising on the external website you are now entering. Do you have high blood pressure? Trigg, I. There are other drugs available to treat your condition. You may take Neoral with or without food, but take it the same Neorao each time. This can lead to serious and sometimes fatal conditions, including cancer, a severe brain infection that can lead to disability Neorl death, or a virus that can cause failure of a transplanted kidney. This may cause side effects such as muscle pain and weakness. Your medicine could harm them. Your blood pressure will also be measured regularly. Your doctor may monitor you with certain blood tests before and during treatment with cyclosporine. Contacts and Locations. You may not be able to use Neoral if you have kidney disease, untreated or uncontrolled hypertension high blood pressureany type of cancer, or psoriasis that has been treated with PUVA, UVB, radiation, methotrexate Trexallor coal tar. The two treatment groups were compared descriptively using summary statistics and comparisons between treatment groups were made using appropriate statistical significance tests. Most people benefit from taking this medicine, but a few people can be upset by it. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided Neorap. Additional information Electronic Publication. Breast-feeding: This medication passes into breast milk. How does this medication work? Skin Neroal warning. For women who are breastfeeding: Cyclosporine passes through breast milk and may cause serious negative effects. Cyclosporin is not a first-line agent. Boxed Warning: Prescribe only by physicians experienced in immunosuppresive therapy. Learn the specific drugs, their uses, risks, and more. In particular tell your doctor it you are taking any of the following:. Be fully aware with immunosuppresive therapy before prescribing. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Convulsions with high-dose methylprednisolone. Eczema : Prescription Medication Options Table. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. Or your symptoms of RA or psoriasis may return. Do not receive a "live" vaccine while using Neoral.
Cyclosporine lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.
Cyclosporine is used to prevent organ rejection after a kidney, liver, or heart transplant.
Dosage and direction
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended.
You may take cyclosporine with or without food, but take it the same way each time. Cyclosporine should be given in two separate doses each day. Try to take the medication at the same dosing times each day. Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon.
Avoid exposure to sunlight, sunlamps, or tanning beds. Cyclosporine can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF 15 or higher) when you are outdoors.
If you are being treated for psoriasis, you should not receive light therapy (PUVA or UVB) or radiation treatments while you are receiving cyclosporine. Make sure all doctors involved in your care know you are taking cyclosporine.
You should not use this medication if you are allergic to cyclosporine. You may not be able to use cyclosporine if you have:
untreated or uncontrolled high blood pressure; or
any type of cancer.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take cyclosporine:
psoriasis that has been treated with PUVA, UVB, radiation, methotrexate (Trexall), or coal tar; or
if you are also taking an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), etodolac (Lodine), indomethacin (Indocin), and others.
It is not known whether cyclosporine is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Cyclosporine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Possible side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
urinating less than usual or not at all;
drowsiness, confusion, mood changes, increased thirst;
swelling, weight gain, feeling short of breath;
blurred vision, headache or pain behind your eyes, sometimes with vomiting;
muscle pain or weakness, fast heart rate, feeling light-headed;
signs of infection such as fever, chills, sore throat, flu symptoms;
pale skin, easy bruising or bleeding, unusual weakness; or
nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
tremors or shaking;
increased hair growth;
headache or body pain;
diarrhea, constipation, vomiting; or
numbness or tingly feeling.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Many drugs can interact with cyclosporine. Below is just a partial list. Tell your doctor about all other medications you are using, especially: etoposide (VePesid, Etopophos); lithium (Eskalith, Lithobid); methotrexate (Rheumatrex, Trexall); nefazodone; repaglinide (Prandin); St. John's wort;
an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik);
a heart or blood pressure medication such as candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro, Avalide), losartan (Cozaar, Hyzaar), valsartan (Diovan), telmisartan (Micardis), or olmesartan (Benicar);
medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);
other medicines used to prevent organ transplant rejection, such as sirolimus (Rapamune) or tacrolimus (Prograf);
pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), diclofenac (Voltaren), etodolac (Lodine), ibuprofen (Advil, Motrin), indomethacin (Indocin), naproxen (Aleve, Naprosyn), and others;
IV antibiotics such as amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet), amikacin (Amikin), bacitracin (Baci-IM), capreomycin (Capastat), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, or vancomycin (Vancocin, Vancoled);
antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir); or
cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid).
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose can cause nausea, vomiting, pain in your upper stomach, loss of appetite, jaundice (yellowing of the skin or eyes), and urinating less than usual or not at all.
Store cyclosporine at room temperature away from moisture and heat.
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. The specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.